Integration of DNA Damage and Repair with Murine Double-Minute 2 (Mdm2) in Tumorigenesis

Integration of DNA Damage and Repair with Murine Double-Minute 2 (Mdm2) in Tumorigenesis

The alteration of tumorigenic pathways leading to cancer is a degenerative disease process typically involving inactivation of tumor suppressor proteins and hyperactivation of oncogenes. One such oncogenic protein product is the murine double-minute 2, or Mdm2. While, Mdm2 has been primarily associa...

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Bibliographic Details
Main Authors: Lindsey D. Mayo, Jason A. Lehman
Format: Article
Language:English
Published: MDPI AG 2012-12-01
Series:International Journal of Molecular Sciences
Subjects:
base excision repair
cancer
homologous recombination
mismatch repair
murine double minute-2
non-homologous end joining
nucleotide excision repair
Online Access:http://www.mdpi.com/1422-0067/13/12/16373

Internet

http://www.mdpi.com/1422-0067/13/12/16373

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