Common themes and unique proteins for the uptake and trafficking of nickel, a metal essential for the virulence of Helicobacter pylori

Common themes and unique proteins for the uptake and trafficking of nickel, a metal essential for the virulence of Helicobacter pylori

Nickel is a virulence determinant for the human gastric pathogen Helicobacter pylori. Indeed, H. pylori possesses two nickel-enzymes that are essential for in vivo colonization, [NiFe] hydrogenase and urease, an abundant virulence factor that contains 24 nickel ions per active complex. Because of th...

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Bibliographic Details
Main Authors: Hilde eDe Reuse, Daniel eVinella, Christine eCavazza
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Helicobacter pylori
Hydrogenase
Nickel
metal trafficking
urease maturation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00094/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00094/full

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