[18F]-BMS-747158-02PET imaging for evaluating hepatic mitochondrial complex 1dysfunction in a mouse model of non-alcoholic fatty liver disease

[18F]-BMS-747158-02PET imaging for evaluating hepatic mitochondrial complex 1dysfunction in a mouse model of non-alcoholic fatty liver disease

Abstract Background Mitochondrial dysfunction is one of the main causes of non-alcohol fatty liver disease (NAFLD). [18F]-BMS-747158-02 (18F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to bind mitochondrial complex-1 (MC-1). The aim of this study was to i...

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Bibliographic Details
Main Authors: Takemi Rokugawa, Sotaro Momosaki, Miwa Ito, Hitoshi Iimori, Yuki Kato, Kohji Abe
Format: Article
Language:English
Published: SpringerOpen 2017-12-01
Series:EJNMMI Research
Subjects:
[18F]-BMS747158-02
Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Mitochondrial complex-1
Methionine- and choline-deficient diet
Positron emission tomography
Online Access:http://link.springer.com/article/10.1186/s13550-017-0345-5

Internet

http://link.springer.com/article/10.1186/s13550-017-0345-5

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