Genome‐wide meta‐analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans

Genome‐wide meta‐analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans

Abstract Background Left ventricular (LV) hypertrophy affects up to 43% of African Americans (AAs). Antihypertensive treatment reduces LV mass (LVM). However, interindividual variation in LV traits in response to antihypertensive treatments exists. We hypothesized that genetic variants may modify th...

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Bibliographic Details
Main Authors: Anh N. Do, Wei Zhao, Abigail S. Baldridge, Laura M. Raffield, Kerri L. Wiggins, Sanjiv J. Shah, Stella Aslibekyan, Hemant K. Tiwari, Nita Limdi, Degui Zhi, Colleen M. Sitlani, Kent D. Taylor, Bruce M. Psaty, Nona Sotoodehnia, Jennifer A. Brody, Laura J. Rasmussen‐Torvik, Donald Lloyd‐Jones, Leslie A. Lange, James G. Wilson, Jennifer A. Smith, Sharon L. R. Kardia, Thomas H. Mosley, Ramachandran S. Vasan, Donna K. Arnett, Marguerite R. Irvin
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
antihypertensive treatment
GWAS
left ventricular trait
pharmacogenetics
Online Access:https://doi.org/10.1002/mgg3.788

Internet

https://doi.org/10.1002/mgg3.788

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