Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation

Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation

Aggregation of α-synuclein (αSyn) into proteinaceous deposits is a pathological hallmark of a range of neurodegenerative diseases including Parkinson’s disease (PD). Numerous lines of evidence indicate that the accumulation of toxic oligomeric and prefibrillar αSyn species may underpin the cellular...

Full description

Bibliographic Details
Main Authors: Blagovesta Popova, Dan Wang, Abirami Rajavel, Karthikeyan Dhamotharan, Diana F. Lázaro, Jennifer Gerke, Joachim F. Uhrig, Michael Hoppert, Tiago F. Outeiro, Gerhard H. Braus
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
α-synuclein
Parkinson’s disease
protein aggregation
oligomerization
peptide drug discovery
yeast
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.659926/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.659926/full

Similar Items