Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors

Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors

Purpose: This paper concerns the cytotoxicity of 9-chloro-1-nitroacridine (1a) and 9-chloro-4-methyl-1-nitroacridine (1b) against two biologically different melanoma forms: melanotic and amelanotic. Melanomas are tumors characterized by high heterogeneity and poor susceptibility to chemotherapies. A...

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Bibliographic Details
Main Authors: Miroslawa Cichorek, Anna Ronowska, Krystyna Dzierzbicka, Monika Gensicka-Kowalewska, Milena Deptula, Iwona Pelikant-Malecka
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chloroacridine
Amelanotic melanoma
Melanotic melanoma
Apoptosis
Tricarboxylic acid cycle enzymes
Cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220307083

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http://www.sciencedirect.com/science/article/pii/S0753332220307083

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