Inhibition of TGF‐β Increases Bone Volume and Strength in a Mouse Model of Osteogenesis Imperfecta

Inhibition of TGF‐β Increases Bone Volume and Strength in a Mouse Model of Osteogenesis Imperfecta

ABSTRACT Osteogenesis imperfecta (OI), is a genetic disorder of bone fragility caused by mutations in collagen I or proteins involved in collagen processing. Previous studies in mice and human OI bones have shown that excessive activation of TGF‐β signaling plays an important role in dominant and re...

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Bibliographic Details
Main Authors: Benjamin Greene, Ryan J Russo, Shannon Dwyer, Katie Malley, Errin Roberts, Joseph Serrielo, Peter Piepenhagen, Sheila Cummings, Susan Ryan, Christine Zarazinski, Sasidhar Uppuganti, Nikolai Bukanov, Jeffry S Nyman, Megan K Cox, Shiguang Liu, Oxana Ibraghimov‐Beskrovnaya, Yves Sabbagh
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:JBMR Plus
Subjects:
BIOCHEMICAL MARKERS OF BONE TURNOVER
OSTEOBLASTS
OSTEOCLASTS
OSTEOGENESIS IMPERFECTA
TGF‐β
Online Access:https://doi.org/10.1002/jbm4.10530

Internet

https://doi.org/10.1002/jbm4.10530

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