A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

Abstract Background The clinical development of a single encounter treatment for uncomplicated malaria has the potential to significantly improve the effectiveness of antimalarials. Exploratory data suggested that the combination of artefenomel and piperaquine phosphate (PQP) has the potential to ac...

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Bibliographic Details
Main Authors: Fiona Macintyre, Yeka Adoke, Alfred B. Tiono, Tran Thanh Duong, Ghyslain Mombo-Ngoma, Marielle Bouyou-Akotet, Halidou Tinto, Quique Bassat, Saadou Issifou, Marc Adamy, Helen Demarest, Stephan Duparc, Didier Leroy, Bart E. Laurijssens, Sophie Biguenet, Afizi Kibuuka, Antoinette Kitoto Tshefu, Melnick Smith, Chanelle Foster, Illse Leipoldt, Peter G. Kremsner, Bui Quang Phuc, Alphonse Ouedraogo, Michael Ramharter, on behalf of the OZ-Piperaquine Study Group
Format: Article
Language:English
Published: BMC 2017-10-01
Series:BMC Medicine
Subjects:
Artefenomel
OZ439
Piperaquine
Single dose combination treatment
Pharmacokinetics
Dose–response
Online Access:http://link.springer.com/article/10.1186/s12916-017-0940-3

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http://link.springer.com/article/10.1186/s12916-017-0940-3

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