Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice

Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice

Abstract Serotonin (5-HT)-based antidepressants, selective serotonin reuptake inhibitors (SSRIs) aim to enhance serotonergic activity by blocking its reuptake. We propose PTEN as a target for an alternative approach for regulating 5-HT neuron activity in the brain and depressive behaviors. We show t...

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Bibliographic Details
Main Authors: Ling Chen, Wan-Kun Gong, Cui-ping Yang, Chan-Chan Shao, Ning-Ning Song, Jia-Yin Chen, Li-Qiang Zhou, Kun-Shan Zhang, Siguang Li, Zhili Huang, Gal Richter-Levin, Lin Xu, Yu-Qiang Ding
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01303-z

Internet

https://doi.org/10.1038/s41398-021-01303-z

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