Gly482Ser PGC-1a gene polymorphism and exercise-related oxidative stress in Amyotrophic Lateral Sclerosis patients

Gly482Ser PGC-1a gene polymorphism and exercise-related oxidative stress in Amyotrophic Lateral Sclerosis patients

The role of exercise in Amyotrophic Lateral Sclerosis (ALS) pathogenesis is controversial and unclear. Exercise induces a pleiotropic adaptive response in skeletal muscle, largely through the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a transcriptional coactivator that reg...

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Bibliographic Details
Main Authors: Angelique ePasquinelli, Lucia eChico, Livia ePasquali, Costanza eBisordi, Annalisa eLo Gerfo, Monica eFabbrini, Lucia ePetrozzi, Letizia eMarconi, Elena eCaldarazzo Ienco, Michelangelo eMancuso, Gabriele eSiciliano
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Exercise
Oxidative Stress
Polymorphism, Single Nucleotide
Amyotrophic lateral sclerosis (ALS)
PGC-1α
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00102/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00102/full

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