Repression of PDK1- and LncRNA HOTAIR-Mediated EZH2 Gene Expression Contributes to the Enhancement of Atractylenolide 1 and Erlotinib in the Inhibition of Human Lung Cancer Cells

Repression of PDK1- and LncRNA HOTAIR-Mediated EZH2 Gene Expression Contributes to the Enhancement of Atractylenolide 1 and Erlotinib in the Inhibition of Human Lung Cancer Cells

Background/Aims: We previously showed that the major bioactive compound of Atractylodes macrocephula Koidz atractylenolide 1 (ATL-1) inhibited human lung cancer cell growth by suppressing the gene expression of 3-Phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1). However, the potentially a...

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Bibliographic Details
Main Authors: Qian Xiao, Fang Zheng, Qing Tang, Jing-Jing Wu, Jianhui Xie, Hai-Ding Huang, Xiao-bo Yang, Swei Sunny Hann
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Atractylenolide 1
Erlotinib
PDK1
HOTAIR
EZH2
Human lung cancer cells
Online Access:https://www.karger.com/Article/FullText/493497

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https://www.karger.com/Article/FullText/493497

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