Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement.

Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement.

T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise mechanisms regulating HIV-1 transcription in lymph nodes (LNs)...

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Bibliographic Details
Main Authors: Riddhima Banga, Caterina Rebecchini, Francesco Andrea Procopio, Alessandra Noto, Olivia Munoz, Kalliopi Ioannidou, Craig Fenwick, Khalid Ohmiti, Matthias Cavassini, Jean-Marc Corpataux, Laurence de Leval, Giuseppe Pantaleo, Matthieu Perreau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007918

Internet

https://doi.org/10.1371/journal.ppat.1007918

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