Implications of Lifestyle Factors and Polygenic Risk Score for Absolute Risk Prediction of Colorectal Neoplasm and Risk-Adapted Screening

Implications of Lifestyle Factors and Polygenic Risk Score for Absolute Risk Prediction of Colorectal Neoplasm and Risk-Adapted Screening

Background: Estimation of absolute risk of developing colorectal neoplasm is essential for personalized colorectal cancer (CRC) screening. We developed models to determine relative and absolute risks of colorectal neoplasm based on lifestyle and genetic variants and to validate their application in...

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Bibliographic Details
Main Authors: Hongda Chen, Li Liu, Ming Lu, Yuhan Zhang, Bin Lu, Ying Zhu, Jianbo Tian, Xinying Li, Shaofa Nie, Xiaoping Miao, Min Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
colorectal cancer
adenoma
polygenic risk score
risk stratification
personalized screening
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.685410/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.685410/full

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