Molecular Dynamics Simulations Predict That rSNP Located in the <i>HNF‑1α</i> Gene Promotor Region Linked with MODY3 and Hepatocellular Carcinoma Promotes Stronger Binding of the HNF‑4α Transcription Factor

Molecular Dynamics Simulations Predict That rSNP Located in the <i>HNF‑1α</i> Gene Promotor Region Linked with MODY3 and Hepatocellular Carcinoma Promotes Stronger Binding of the HNF‑4α Transcription Factor

Our study aims to investigate the impact of the Maturity-onset diabetes of the young 3 disease-linked rSNP rs35126805 located in the <i>HNF‑1α</i> gene promotor on the binding of the transcription factor HNF‑4α and consequently on the regulation of <i>HNF‑1α</i> gene expressi...

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Bibliographic Details
Main Authors: Eva Španinger, Uroš Potočnik, Urban Bren
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomolecules
Subjects:
HNF‑1α
HNF‑4α
MODY3
rSNP
molecular dynamics
binding free energy
Online Access:https://www.mdpi.com/2218-273X/10/12/1700

Internet

https://www.mdpi.com/2218-273X/10/12/1700

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