Off-Target Deletion of Conditional <i>Dbc1</i> Allele in the <i>Foxp3</i><sup>YFP-Cre</sup> Mouse Line under Specific Setting

Off-Target Deletion of Conditional <i>Dbc1</i> Allele in the <i>Foxp3</i><sup>YFP-Cre</sup> Mouse Line under Specific Setting

The Cre-LoxP conditional knockout strategy has been used extensively to study gene function in a specific cell-type. In this study, the authors tried to engineer mice in which the <i>Dbc1</i> gene is conditionally knocked out in Treg cells. Unexpectedly, the conditional <i>Dbc1<...

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Bibliographic Details
Main Authors: Chichu Xie, Fangming Zhu, Julie Wang, Weizhou Zhang, Joseph A. Bellanti, Bin Li, David Brand, Nancy Olsen, Song Guo Zheng
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
foxp3
cre
off-target
germline recombination
Online Access:https://www.mdpi.com/2073-4409/8/11/1309

Internet

https://www.mdpi.com/2073-4409/8/11/1309

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