Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels

Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels

Abstract Background Grb2-associated binder 2 (Gab2) is a scaffolding protein that serves as a critical signaling amplifier downstream of tyrosine kinase receptors. Our previous study has shown that Gab2 induces epithelial-to-mesenchymal transition (EMT) and promotes metastasis in colorectal cancer (...

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Bibliographic Details
Main Authors: Chenbo Ding, Junmin Luo, Xiaobo Fan, Longmei Li, Shanshan Li, Kunming Wen, Jihong Feng, Guoqiu Wu
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gab2
Colorectal cancer
Angiogenesis
VEGF
Online Access:http://link.springer.com/article/10.1186/s13046-017-0524-2

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http://link.springer.com/article/10.1186/s13046-017-0524-2

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