Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis

Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis

Background/Aims: Diabetic non-healing skin ulcers represent a serious challenge in clinical practice, in which the hyperglycemia-induced disturbance of angiogenesis, and endothelial dysfunction play a crucial role. Resveratrol (RES), a silent information regulator 1 (SIRT1) agonist, can improve endo...

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Bibliographic Details
Main Authors: Xiaozhong Huang, Jia Sun, Gen Chen, Chao Niu, Ying Wang, Congcong Zhao, Jian Sun, Huiya Huang, Shuai Huang, Yangzhi Liang, Yingjie Shen, Weitao Cong, Litai Jin, Zhongxin Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
angiogenesis
diabetic wound healing
endothelial dysfunction
silent information regulator 1
forkhead box O1
c-Myc
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00421/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00421/full

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