Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational Molecular Modeling and in vitro Assay

Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational Molecular Modeling and in vitro Assay

Hallmarks of Alzheimer’s disease (AD) pathology include acetylcholine (ACh) deficiency and plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact with amyloid β (Aβ) to promote aggregation of insoluble Aβ plaques in brains of patients. Current therapeutic options a...

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Bibliographic Details
Main Authors: Aimi Syamima Abdul Manap, Amelia Cheng Wei Tan, Weng Hhin Leong, Adeline Yoke Yin Chia, Shantini Vijayabalan, Aditya Arya, Eng Hwa Wong, Farzana Rizwan, Umesh Bindal, Shajan Koshy, Priya Madhavan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
amyloid beta
acetylcholinesterase
curcumin
piperine
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00206/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00206/full

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