Cystatin B Involvement in Synapse Physiology of Rodent Brains and Human Cerebral Organoids

Cystatin B Involvement in Synapse Physiology of Rodent Brains and Human Cerebral Organoids

Cystatin B (CSTB) is a ubiquitous protein belonging to a superfamily of protease inhibitors. CSTB may play a critical role in brain physiology because its mutations cause progressive myoclonic epilepsy-1A (EPM1A), the most common form of progressive myoclonic epilepsy. However, the molecular mechani...

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Bibliographic Details
Main Authors: Eduardo Penna, Angela Cerciello, Angela Chambery, Rosita Russo, Filippo M. Cernilogar, Emilia Maria Pedone, Carla Perrone-Capano, Silvia Cappello, Rossella Di Giaimo, Marianna Crispino
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
CSTB
synaptosomes
EPM1A
cerebral organoids
synaptic plasticity
local protein synthesis
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00195/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00195/full

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