Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis

Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis

Background: Innate immune response components such as toll-like receptors (TLRs) and NLRP3-inflammasome act in concert to increase IL-1α/β secretion by synovial macrophages. Previous results suggest that IL-1α/β could be an important mediator involved in the pathogenesis of osteoarthritis (OA).Objec...

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Bibliographic Details
Main Authors: Sonia Nasi, Hang-Korng Ea, Alexander So, Nathalie Busso
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Pharmacology
Subjects:
NLRP3 inflammasome
interleukin-1β
cartilage
knock-out mice
animal model of OA
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00282/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00282/full

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