Antiplatelet and Antithrombotic Activities of Non-Steroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

Antiplatelet and Antithrombotic Activities of Non-Steroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

Nonsteroidal anti-inflammatory drugs (NSAIDs) 1–5 containing an N-acyl hydrazone subunit were prepared and their antiplatelet and antithrombotic activities assessed in vitro and in vivo. Compounds 1–5 inhibited the platelet aggregation induced by adenosine diphosphate and/or arachidonic acid, with i...

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Bibliographic Details
Main Authors: Rafael Consolin Chelucci, Luiz Antônio Dutra, Maria Elisa Lopes Pires, Thais Regina Ferreira de Melo, Priscila Longhin Bosquesi, Man Chin Chung, Jean Leandro dos Santos
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Molecules
Subjects:
hydrazone
antiplatelet
antithrombotic
NSAIDs
bleeding time
Online Access:http://www.mdpi.com/1420-3049/19/2/2089

Internet

http://www.mdpi.com/1420-3049/19/2/2089

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