The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG

The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG

Summary: TMEM18 is the strongest candidate for childhood obesity identified from GWASs, yet as for most GWAS-derived obesity-susceptibility genes, the functional mechanism remains elusive. We here investigate the relevance of TMEM18 for adipose tissue development and obesity. We demonstrate that adi...

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Bibliographic Details
Main Authors: Kathrin Landgraf, Nora Klöting, Martin Gericke, Nitzan Maixner, Esther Guiu-Jurado, Markus Scholz, A. Veronica Witte, Frauke Beyer, Julian T. Schwartze, Martin Lacher, Arno Villringer, Peter Kovacs, Assaf Rudich, Matthias Blüher, Wieland Kiess, Antje Körner
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
TMEM18
adipose progenitor cells
adipogenesis
PPARG
adipose tissue
children
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312845

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720312845

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