STAT3 or USF2 contributes to HIF target gene specificity.

STAT3 or USF2 contributes to HIF target gene specificity.

The HIF1- and HIF2-mediated transcriptional responses play critical roles in solid tumor progression. Despite significant similarities, including their binding to promoters of both HIF1 and HIF2 target genes, HIF1 and HIF2 proteins activate unique subsets of target genes under hypoxia. The mechanism...

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Bibliographic Details
Main Authors: Matthew R Pawlus, Liyi Wang, Aya Murakami, Guanhai Dai, Cheng-Jun Hu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3749168?pdf=render

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http://europepmc.org/articles/PMC3749168?pdf=render

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