Overcoming Drug Resistance in Colon Cancer by Aptamer-Mediated Targeted Co-Delivery of Drug and siRNA Using Grapefruit-Derived Nanovectors

Overcoming Drug Resistance in Colon Cancer by Aptamer-Mediated Targeted Co-Delivery of Drug and siRNA Using Grapefruit-Derived Nanovectors

Background/Aims: Multidrug resistance (MDR) is the most common cause of chemotherapy failure. Upregulation of P-glycoprotein (P-gp) is one of the main mechanisms underlying MDR. Methods: In this study, we developed a targeted drug and small interfering (si)RNA co-delivery system based on specific ap...

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Bibliographic Details
Main Authors: Wei Yan, Mingyue Tao, Baofei Jiang, Mengchu Yao, Yali Jun, Weijie Dai, Zhuang Tang, Yong Gao, Li Zhang, Xiaofei Chen, Qi-long Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Multidrug resistance
Cancer therapy
Aptamer
Grapefruit-derived nanovectors
Drug delivery
Online Access:https://www.karger.com/Article/FullText/493960

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https://www.karger.com/Article/FullText/493960

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