Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells

Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells

Signal transducers and activators of transcription (Stats) play central roles in the conversion of extracellular signals, e.g., cytokines, hormones and growth factors, into tissue and cell type specific gene expression patterns. In normal cells, their signaling potential is strictly limited in exten...

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Bibliographic Details
Main Authors: Axel Weber, Corina Borghouts, Christian Brendel, Richard Moriggl, Natalia Delis, Boris Brill, Vida Vafaizadeh, Bernd Groner
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Cancers
Subjects:
peptide aptamer (PA)
signal transducer and activator of transcription 5 (Stat5)
RNA interference (RNAi)
protein/lentiviral transduction
chronic myeloid leukemia (CML)
human erythroid leukemia (HEL)
Bcr-Abl
Jak2(V617F)
canonical/non-canonical
Online Access:http://www.mdpi.com/2072-6694/7/1/503

Internet

http://www.mdpi.com/2072-6694/7/1/503

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