Interferon-Gamma DNA Methylation Is Affected by Mycophenolic Acid but Not by Tacrolimus after T-Cell Activation

Interferon-Gamma DNA Methylation Is Affected by Mycophenolic Acid but Not by Tacrolimus after T-Cell Activation

Immunosuppressive drug therapy is required to treat patients with autoimmune disease and patients who have undergone organ transplantation. The main targets of the immunosuppressive drugs tacrolimus and mycophenolic acid (MPA; the active metabolite of mycophenolate mofetil) are T cells. It is curren...

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Bibliographic Details
Main Authors: Fleur S. Peters, Annemiek M. A. Peeters, Leo J. Hofland, Michiel G. H. Betjes, Karin Boer, Carla C. Baan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
interferon-gamma
epigenetics
polyclonal activation
remethylation
transplantation immunology
in vitro
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00822/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00822/full

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