Reciprocal modulation between amyloid precursor protein and synaptic membrane cholesterol revealed by live cell imaging

Reciprocal modulation between amyloid precursor protein and synaptic membrane cholesterol revealed by live cell imaging

The amyloid precursor protein (APP) has been extensively studied because of its association with Alzheimer's disease (AD). However, APP distribution across different subcellular membrane compartments and its function in neurons remains unclear. We generated an APP fusion protein with a pH-sensi...

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Bibliographic Details
Main Authors: Claire E. DelBove, Claire E. Strothman, Roman M. Lazarenko, Hui Huang, Charles R. Sanders, Qi Zhang
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Neurobiology of Disease
Subjects:
Amyloid precursor protein
Trafficking
Proteolysis
Membrane
Cholesterol
Synapse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118306934

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http://www.sciencedirect.com/science/article/pii/S0969996118306934

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