Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells

Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells

Abstract Background p21-activated kinase 1 (PAK1) plays a fundamental role in promoting the development and progression of several cancers and is a potential therapeutic target. However, the biological function and underlying mechanism of PAK1 in esophageal squamous cell carcinoma (ESCC) remain uncl...

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Bibliographic Details
Main Authors: Liang Chen, Shuning Bi, Jiuzhou Hou, Zhijun Zhao, Chaojie Wang, Songqiang Xie
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cell Communication and Signaling
Subjects:
ESCC
PAK1
Metastasis
IPA-3
Raf1
MEK1
Online Access:http://link.springer.com/article/10.1186/s12964-019-0343-5

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http://link.springer.com/article/10.1186/s12964-019-0343-5

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