Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

Abstract Immune checkpoint inhibitor (ICI) treatments produce clinical benefit in many patients. However, better pretreatment predictive biomarkers for ICI are still needed to help match individual patients to the treatment most likely to be of benefit. Existing gene expression profiling (GEP)-based...

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Bibliographic Details
Main Authors: Chuanliang Cui, Canqiang Xu, Wenxian Yang, Zhihong Chi, Xinan Sheng, Lu Si, Yihong Xie, Jinyu Yu, Shun Wang, Rongshan Yu, Jun Guo, Yan Kong
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-021-00169-w

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https://doi.org/10.1038/s41525-021-00169-w

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