Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

Abstract Background The apolipoprotein E ε4 (APOE4) genotype is a prominent late-onset Alzheimer’s disease (AD) risk factor. ApoE4 disrupts memory function in rodents and may contribute to both plaque and tangle formation. Methods Coimmunoprecipitation and Western blot detection were used to determi...

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Bibliographic Details
Main Authors: Hoau-Yan Wang, Caryn Trocmé-Thibierge, Andres Stucky, Sanket M. Shah, Jessica Kvasic, Amber Khan, Philippe Morain, Isabelle Guignot, Eva Bouguen, Karine Deschet, Maria Pueyo, Elisabeth Mocaer, Pierre-Jean Ousset, Bruno Vellas, Vera Kiyasova
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Mild cognitive impairment
β-Amyloid
Apolipoprotein E
α7 Nicotinic acetylcholine receptor
tau phosphorylation
Online Access:http://link.springer.com/article/10.1186/s13195-017-0280-8

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http://link.springer.com/article/10.1186/s13195-017-0280-8

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