In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2

In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2

Successful in situ therapeutic vaccination would allow locally delivered oncolytic virus (OV) to exert systemic immunologic effects on metastases and improve survival. We have utilized bilateral flank tumor models to determine the most efficacious regimens of in situ vaccination. Intratumoral inject...

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Bibliographic Details
Main Authors: Weilin Liu, Enyong Dai, Zuqiang Liu, Congrong Ma, Zong Sheng Guo, David L. Bartlett
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virus
colorectal cancer
lung cancer
in situ cancer vaccine
CpG
systemic anti-tumor immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770520300565

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http://www.sciencedirect.com/science/article/pii/S2372770520300565

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