Extracellular and macropinocytosis internalized ATP work together to induce epithelial–mesenchymal transition and other early metastatic activities in lung cancer

Extracellular and macropinocytosis internalized ATP work together to induce epithelial–mesenchymal transition and other early metastatic activities in lung cancer

Abstract Background Extracellular ATP (eATP) was shown to induce epithelial–mesenchymal transition (EMT), a very important early process in metastasis, in cancer cells via purinergic receptor signaling. However, the exact induction mechanisms are far from fully known. We previously described that eA...

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Bibliographic Details
Main Authors: Yanyang Cao, Xuan Wang, Yunsheng Li, Maria Evers, Haiyun Zhang, Xiaozhuo Chen
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Cancer Cell International
Subjects:
Tumor microenvironment
Invasion
EMT
ATP internalization
TGF-β
Online Access:http://link.springer.com/article/10.1186/s12935-019-0973-0

Internet

http://link.springer.com/article/10.1186/s12935-019-0973-0

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