UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity.

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity.

The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-induced thermogenesis.Here we report that cyclooxygenase (COX) activity and prostaglandin E(2) (PGE(2)) are crucially involved in induction of UCP1 expression in inguinal white adipocytes, but not in cla...

Full description

Bibliographic Details
Main Authors: Lise Madsen, Lone M Pedersen, Haldis Haukaas Lillefosse, Even Fjaere, Ingeborg Bronstad, Qin Hao, Rasmus K Petersen, Philip Hallenborg, Tao Ma, Rita De Matteis, Pedro Araujo, Josep Mercader, M Luisa Bonet, Jacob B Hansen, Barbara Cannon, Jan Nedergaard, Jun Wang, Saverio Cinti, Peter Voshol, Stein Ove Døskeland, Karsten Kristiansen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2894971?pdf=render

Internet

http://europepmc.org/articles/PMC2894971?pdf=render

Similar Items