Destabilizing DNA during Rejoining Enhances Fidelity of Repair.

A new study shows that during repair of DNA, the effect of a single-strand annealing protein is to destabilize DNA duplex formation so that annealing only occurs between perfectly matched strands; the protein then clamps the strands together for repair. Read the Research Article.

Bibliographic Details
Main Author: Richard Robinson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-08-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4535887?pdf=render