Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis

Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis

We analyzed chromatin dynamics and transcriptional activity of human embryonic stem cell (hESC)-derived cardiac progenitor cells (CPCs) and KDR+/CD34+ endothelial cells generated from different mesodermal origins. Using an unbiased algorithm to hierarchically rank genes modulated at the level of chr...

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Bibliographic Details
Main Authors: Nathan J. Palpant, Yuliang Wang, Brandon Hadland, Rebecca J. Zaunbrecher, Meredith Redd, Daniel Jones, Lil Pabon, Rajan Jain, Jonathan Epstein, Walter L. Ruzzo, Ying Zheng, Irwin Bernstein, Adam Margolin, Charles E. Murry
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
human pluripotent stem cell
cardiovascular
hematopoiesis
chromatin dynamics
differentiation
genome engineering
Wnt signaling
epigenetics
cardiac
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310604

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http://www.sciencedirect.com/science/article/pii/S2211124717310604

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