Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome

Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome

<p>Abstract</p> <p>Background</p> <p>Fragile X syndrome (FXS) is caused by the absence of the mRNA-binding protein Fragile X mental retardation protein (FMRP), encoded by the <it>Fmr1</it> gene. Overactive signaling by group 1 metabotropic glutamate receptor...

Full description

Bibliographic Details
Main Authors: Xu Zhao-Hui, Yang Qi, Feng Bin, Liu Shui-bing, Zhang Nan, Xing Jiang-hao, Li Xiao-Qiang, Wu Yu-mei, Gao Guo-Dong, Zhao Ming-Gao
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Molecular Neurodegeneration
Subjects:
Group I mGluRs
Dopamine
Long-term potentiation prefrontal cortex
Online Access:http://www.molecularneurodegeneration.com/content/7/1/24

Internet

http://www.molecularneurodegeneration.com/content/7/1/24

Similar Items