A Dual Molecular Biointerface Combining RGD and KRSR Sequences Improves Osteoblastic Functions by Synergizing Integrin and Cell-Membrane Proteoglycan Binding

A Dual Molecular Biointerface Combining RGD and KRSR Sequences Improves Osteoblastic Functions by Synergizing Integrin and Cell-Membrane Proteoglycan Binding

Synergizing integrin and cell-membrane heparan sulfate proteoglycan signaling on biomaterials through peptidic sequences is known to have beneficial effects in the attachment and behavior of osteoblasts; however, controlling the exact amount and ratio of peptides tethered on a surface is challenging...

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Bibliographic Details
Main Authors: Mireia Hoyos-Nogués, Elena Falgueras-Batlle, Maria-Pau Ginebra, José María Manero, Javier Gil, Carlos Mas-Moruno
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
biointerface
titanium
functionalization
RGD
integrin
KRSR
proteoglycan
osteointegration
osteoblast
coating
Online Access:https://www.mdpi.com/1422-0067/20/6/1429

Internet

https://www.mdpi.com/1422-0067/20/6/1429

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