Tandospirone enhances the anti-myocardial fibrosis effect of valsartan in spontaneously hypertensive rats

Tandospirone enhances the anti-myocardial fibrosis effect of valsartan in spontaneously hypertensive rats

Purpose: Myocardial fibrosis (MF) is an unavoidable complication in patients with hypertensive heart disease. Valsartan, a widely used antihypertensive drug, was reported to inhibit MF. Deficiency in the 5-hydroxytryptamine (5-HT, serotonin) transporter gene has been proven to cause MF. Long-term sy...

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Bibliographic Details
Main Authors: Xuefei Huang, Yaqi Kang, Xinrui Jiang, Jing Yang, An-Guo Wu, Chuanqing Zhang, Dalian Qin, Shousong Cao, Qibin Mei, Yun Ye, Jianming Wu
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tandospirone
Valsartan
Hypertension
Myocardial fibrosis
TGF-β1/Smad3
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222030264X

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http://www.sciencedirect.com/science/article/pii/S075333222030264X

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