PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
The immune checkpoint molecule PD-1 is expressed on a fraction of CD4+ T cells latently infected with HIV, but whether PD-1 plays a functional role in reservoir persistence remains unknown. Here, Fromentin et al. show that PD-1 blockade potentiates latency reversal ex vivo in CD4+ T cells from ART s...
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Bibliographic Details
Main Authors: |
Rémi Fromentin,
Sandrina DaFonseca,
Cecilia T. Costiniuk,
Mohamed El-Far,
Francesco Andrea Procopio,
Frederick M. Hecht,
Rebecca Hoh,
Steven G. Deeks,
Daria J. Hazuda,
Sharon R. Lewin,
Jean-Pierre Routy,
Rafick-Pierre Sékaly,
Nicolas Chomont |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2019-02-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-019-08798-7
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