High-throughput screening of clinically approved drugs that prime nonviral gene delivery to human Mesenchymal stem cells

High-throughput screening of clinically approved drugs that prime nonviral gene delivery to human Mesenchymal stem cells

Abstract Background Human mesenchymal stem cells (hMSCs) are intensely researched for applications in cell therapeutics due to their unique properties, however, intrinsic therapeutic properties of hMSCs could be enhanced by genetic modification. Viral transduction is efficient, but suffers from safe...

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Bibliographic Details
Main Authors: Tyler Kozisek, Andrew Hamann, Albert Nguyen, Michael Miller, Sarah Plautz, Angela K. Pannier
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Biological Engineering
Subjects:
Human mesenchymal stem cells
High-throughput screen
NIH clinical collection
Nonviral gene delivery
Priming transfection
Lipoplexes
Online Access:http://link.springer.com/article/10.1186/s13036-020-00238-1

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http://link.springer.com/article/10.1186/s13036-020-00238-1

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