SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancerResearch in context

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancerResearch in context

Background: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC). Methods: Herein we have overexpressed LKB1 in human hepatoma cel...

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Main Authors: Imanol Zubiete-Franco, Juan L. García-Rodríguez, Fernando Lopitz-Otsoa, Marina Serrano-Macia, Jorge Simon, Pablo Fernández-Tussy, Lucía Barbier-Torres, David Fernández-Ramos, Virginia Gutiérrez-de-Juan, Sergio López de Davalillo, Onintza Carlevaris, Adolfo Beguiristain Gómez, Erica Villa, Diego Calvisi, César Martín, Edurne Berra, Patricia Aspichueta, Naiara Beraza, Marta Varela-Rey, Matias Ávila, Manuel S. Rodríguez, José M. Mato, Irene Díaz-Moreno, Antonio Díaz-Quintana, Teresa C. Delgado, María L. Martínez-Chantar
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641830608X

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http://www.sciencedirect.com/science/article/pii/S235239641830608X

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