The HslV Protease from <i>Leishmania major</i> and Its Activation by C-terminal HslU Peptides

The HslV Protease from <i>Leishmania major</i> and Its Activation by C-terminal HslU Peptides

HslVU is an ATP-dependent proteolytic complex present in certain bacteria and in the mitochondrion of some primordial eukaryotes, including deadly parasites such as <i>Leishmania</i>. It is formed by the dodecameric protease HslV and the hexameric ATPase HslU, which binds via the C-termi...

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Bibliographic Details
Main Authors: Ndeye Mathy Kebe, Krishnananda Samanta, Priyanka Singh, Joséphine Lai-Kee-Him, Viviana Apicella, Nadine Payrot, Noémie Lauraire, Baptiste Legrand, Vincent Lisowski, Diane-Ethna Mbang-Benet, Michel Pages, Patrick Bastien, Andrey V. Kajava, Patrick Bron, Jean-François Hernandez, Olivier Coux
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
ATP-dependent protease
HslVU
peptide chemical synthesis
cryo-electron microscopy
Leishmania
mitochondria
allosteric regulation
cyclic peptides
Online Access:https://www.mdpi.com/1422-0067/20/5/1021

Internet

https://www.mdpi.com/1422-0067/20/5/1021

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