Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer’s disease

Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer’s disease

Abstract Background Mitochondrial electron transport chain abnormalities have been reported in postmortem pathological specimens of Alzheimer’s disease (AD). However, it remains unclear how amyloid and tau are associated with mitochondrial dysfunction in vivo. The purpose of this study is to assess...

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Bibliographic Details
Main Authors: Tatsuhiro Terada, Joseph Therriault, Min Su Peter Kang, Melissa Savard, Tharick Ali Pascoal, Firoza Lussier, Cecile Tissot, Yi-Ting Wang, Andrea Benedet, Takashi Matsudaira, Tomoyasu Bunai, Tomokazu Obi, Hideo Tsukada, Yasuomi Ouchi, Pedro Rosa-Neto
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease (AD)
Mitochondria
Tau
Amyloid
PET
[18F]BCPP-EF
Online Access:https://doi.org/10.1186/s13024-021-00448-1

Internet

https://doi.org/10.1186/s13024-021-00448-1

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