Differential Spatio-Temporal Regulation of MMPs in the 5xFAD Mouse Model of Alzheimer’s disease: Evidence for aPro-Amyloidogenic Role of MT1-MMP

Differential Spatio-Temporal Regulation of MMPs in the 5xFAD Mouse Model of Alzheimer’s disease: Evidence for aPro-Amyloidogenic Role of MT1-MMP

Matrix metalloproteinases (MMPs) are pleiotropic endopeptidases involved in a variety of neurodegenerative/neuroinflammatory processes through their interactions with a large number of substrates. Among those, the amyloid precursor protein (APP) and the beta amyloid peptide (Aß) are largely associat...

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Bibliographic Details
Main Authors: Nathalie ePy, Amandine eBonnet, Anne eBernard, Yannick eMarchalant, Eliane eCharrat, Frédéric eChecler, Michel eKhrestchatisky, Kévin eBaranger, Santiago eRivera
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
ADAM Proteins
Cytokines
Neuroinflammation
TIMP
MMP-2
MMP-9
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00247/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00247/full

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