Environmentally induced ribosomal DNA (rDNA) instability in human cells and populations exposed to hexavalent chromium [Cr (VI)]

Environmentally induced ribosomal DNA (rDNA) instability in human cells and populations exposed to hexavalent chromium [Cr (VI)]

Hexavalent Chromium [Cr (VI)] is an established toxicant, carcinogen, and a significant source of public health concern. The multicopy ribosomal DNA (rDNA) array is mechanistically linked to aging and cancer, is the most evolutionarily conserved segment of the human genome, and gives origin to nucle...

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Bibliographic Details
Main Authors: Jianlin Lou, Shoukai Yu, Lingfang Feng, Xinnian Guo, Meng Wang, Alan T. Branco, Tao Li, Bernardo Lemos
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Environment International
Subjects:
Chromium
Ribosome
rDNA
Nucleolus
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Online Access:http://www.sciencedirect.com/science/article/pii/S0160412021001501

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http://www.sciencedirect.com/science/article/pii/S0160412021001501

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