Functional Cross-Talk between the α1- and β1-Adrenergic Receptors Modulates the Rapidly Activating Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes

Functional Cross-Talk between the α1- and β1-Adrenergic Receptors Modulates the Rapidly Activating Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes

The rapidly activating delayed rectifier potassium current (IKr) plays a critical role in cardiac repolarization. Although IKr is known to be regulated by both α1- and β1-adrenergic receptors (ARs), the cross-talk and feedback mechanisms that dictate its response to α1- and β1-AR activation are not...

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Bibliographic Details
Main Authors: Di Xu, Sen Wang, Ting-Ting Wu, Xiao-Yan Wang, Jin Qian, Yan Guo
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
adrenergic receptors
potassium current
cross-talk
arrhythmia
Online Access:http://www.mdpi.com/1422-0067/15/8/14220

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http://www.mdpi.com/1422-0067/15/8/14220

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