A Single TCF Transcription Factor, Regardless of Its Activation Capacity, Is Sufficient for Effective Trilineage Differentiation of ESCs

A Single TCF Transcription Factor, Regardless of Its Activation Capacity, Is Sufficient for Effective Trilineage Differentiation of ESCs

Co-expression and cross-regulation of the four TCF/LEFs render their redundant and unique functions ambiguous. Here, we describe quadruple-knockout (QKO) mouse ESCs lacking all full-length TCF/LEFs and cell lines rescued with TCF7 or TCF7L1. QKO cells self-renew, despite gene expression patterns tha...

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Bibliographic Details
Main Authors: Steven Moreira, Enio Polena, Victor Gordon, Solen Abdulla, Sujeivan Mahendram, Jiayi Cao, Alexandre Blais, Geoffrey A. Wood, Anna Dvorkin-Gheva, Bradley W. Doble
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
TCF/LEF
TCF7L1
TCF7
LEF1
TCFL2
Wnt
β-catenin
ESC
differentiation
pluripotency
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311506

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http://www.sciencedirect.com/science/article/pii/S2211124717311506

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