Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity

Analysis of Indian SARS-CoV-2 Genomes Reveals Prevalence of D614G Mutation in Spike Protein Predicting an Increase in Interaction With TMPRSS2 and Virus Infectivity

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has emerged as a global pandemic worldwide. In this study, we used ARTIC primers–based amplicon sequencing to profile 225 SARS-CoV-2 genomes from India. Phylogenetic analysis of 202...

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Main Authors: Sunil Raghav, Arup Ghosh, Jyotirmayee Turuk, Sugandh Kumar, Atimukta Jha, Swati Madhulika, Manasi Priyadarshini, Viplov K. Biswas, P. Sushree Shyamli, Bharati Singh, Neha Singh, Deepika Singh, Ankita Datey, Kiran Avula, Shuchi Smita, Jyotsnamayee Sabat, Debdutta Bhattacharya, Jaya Singh Kshatri, Dileep Vasudevan, Amol Suryawanshi, Rupesh Dash, Shantibhushan Senapati, Tushar K. Beuria, Rajeeb Swain, Soma Chattopadhyay, Gulam Hussain Syed, Anshuman Dixit, Punit Prasad, Odisha COVID-19 Study Group, ILS COVID-19 Team, Sanghamitra Pati, Ajay Parida, Arvind Kumar Singh, Baijayantimala Mishra, Banajini Parida, Binod Kumar Patro, D. P. Dogra, Dasarathi Das, Deepa Prasad, Dhaneswari Jena, Dharitri Mohapatra, Dinesh Prasad Sahu, Durga Madhab Satapathy, Durgesh Prasad Sahoo, Jayanta Panda, Jaya Singh Khatri, Kaushik Mishra, Manoranjan Satpathy, Nirupama Chaini, Roma Rattan, Sadhu Panda, Sangeeta Das, Somen Kumar Pradhan, Srikanta Kanungo, Sriprasad Mohanty, Subrata Kumar Palo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Microbiology
Subjects:
SARS-CoV-2
COVID-19
phylogeny
India
D614G
viral RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.594928/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.594928/full

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