Early Steps in Herpes Simplex Virus Infection Blocked by a Proteasome Inhibitor

Early Steps in Herpes Simplex Virus Infection Blocked by a Proteasome Inhibitor

Viruses usurp host cell functions to advance their replicative agenda. HSV relies on cellular proteasome activity for successful infection. Proteasome inhibitors, such as MG132, block HSV infection at multiple stages of the infectious cycle. Targeting host cell processes for antiviral intervention i...

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Bibliographic Details
Main Authors: Seth M. Schneider, Suzanne M. Pritchard, George A. Wudiri, Chasity E. Trammell, Anthony V. Nicola
Format: Article
Language:English
Published: American Society for Microbiology 2019-05-01
Series:mBio
Subjects:
antiviral agents
bortezomib
herpes simplex virus
human herpesviruses
proteasome
Online Access:https://doi.org/10.1128/mBio.00732-19

Internet

https://doi.org/10.1128/mBio.00732-19

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