Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that:...

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Bibliographic Details
Main Authors: Nils Landegren, Lindsey B Rosen, Eva Freyhult, Daniel Eriksson, Tove Fall, Gustav Smith, Elise M N Ferre, Petter Brodin, Donald Sharon, Michael Snyder, Michail Lionakis, Mark Anderson, Olle Kämpe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
autoantigen
autoantibody
type 1 diabetes
immune tolerance
APS1/APECED
Online Access:https://elifesciences.org/articles/43578

Internet

https://elifesciences.org/articles/43578

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